Apathy and Depression: Separate Factors in Parkinson's Disease

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apathy, and depression in Parkinson’s disease

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Emotion recognition impairment and apathy after subthalamic nucleus stimulation in Parkinson's disease have separate neural substrates.

OBJECTIVE To test the hypothesis that emotion recognition and apathy share the same functional circuit involving the subthalamic nucleus (STN). METHODS A consecutive series of 17 patients with advanced Parkinson's disease (PD) was assessed 3 months before (M-3) and 3 months (M+3) after STN deep brain stimulation (DBS). Mean (+/-S.D.) age at surgery was 56.9 (8.7) years. Mean disease duration ...

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ژورنال

عنوان ژورنال: Journal of the International Neuropsychological Society

سال: 2011

ISSN: 1355-6177,1469-7661

DOI: 10.1017/s1355617711001068